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BIOTAGE automatic flash chromatography sp1
Automatic Flash Chromatography Sp1, supplied by BIOTAGE, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/sp1+flash+chromatography+system/sp1+flash+chromatography/us12358901-410-9-9
Average 90 stars, based on 1 article reviews
automatic flash chromatography sp1 - by Bioz Stars, 2026-09
90/100 stars

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Related Articles

Column Chromatography:

Article Title: Development of an Orally Bioavailable LCK PROTAC Degrader as a Potential Therapeutic Approach to T-Cell Acute Lymphoblastic Leukemia.
Article Snippet: Despite significant advances over recent years, the treatment of T cell acute lymphoblastic leukemia (T-ALL) remains challenging.. We have recently shown that a subset of T-ALL cases exhibited constitutive activation of the lymphocyte-specific protein tyrosine kinase (LCK) and were consequently responsive to treatments with LCK inhibitors and degraders such as dasatinib and dasatinib-based PROTACs.. Here we report the design, synthesis and in vitro/vivo evaluation of SJ45566, a potent and orally bioavailable LCK PROTAC.

Article Title: Discovery and molecular basis of subtype-selective cyclophilin inhibitors
Article Snippet: Preparative high-performance liquid chromatography (HPLC) reverse phase purification was conducted with an Agilent 6100 Quadrupole liquid chromatography–mass spectrometry (LC–MS) system using a Kinetex 5 μm C18 100 Å, AXIA Packed LC Column 150 ×30.0 mm (Phenomenex). .. Silica gel column chromatography was conducted with a Biotage SP1 Flash Chromatography system. ..

Article Title: Structure-Based Ligand Design Targeting Pseudomonas aeruginosa LpxA in Lipid A Biosynthesis.
Article Snippet: Enzymes involved in lipid A biosynthesis are promising antibacterial drug targets in Gram-negative bacteria.. In this study, we use a structure-based design approach to develop a series of novel tetrazole ligands with low μM affinity for LpxA, the first enzyme in the lipid A pathway.. Aided by previous structural data, X-ray crystallography, and surface plasmon resonance bioanalysis, we identify 17 hit compounds.

Article Title: Heteroaryl phosphonates as non-covalent inhibitors of both serine- and metallo-carbapenemases
Article Snippet: .. Column chromatography was carried out using a Biotage SP1 flash chromatography system and silica gel cartridges from Silicycle. .. Analytical TLC plates from EM Science (Silica Gel 60 F 254 ) were employed for TLC analyses.

Article Title: Preclinical evaluation of proteolytic targeting of LCK as a therapeutic approach in T cell acute lymphoblastic leukemia.
Article Snippet: Thinlayer chromatography was performed using either Merck Millipore silica gel 60G F254 glass plates or Biotage KP-NH plates and visualized with a 254-nm ultraviolet (UV) lamp for detection. .. Automated flash column chromatography was carried out on a Biotage SP1 flash chromatography system using Sfar silica gel, Sfar amino, or SNAP C18 columns. ..

Article Title: Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design
Article Snippet: Thin layer chromatography for monitoring reaction progress was performed using Merck Millipore silica gel 60G F254 glass plates or Biotage KP-NH plates and a 254 nm UV lamp for detection. .. Automated flash column chromatography was conducted on a Biotage SP1 flash chromatography system using Sfar silica, Sfar amino, or SNAP C18 columns. .. NMR spectra were acquired on Bruker 400 MHz or 500 MHz spectrometers in the solvents indicated and spectra were processed using MestReNova v12.

Article Title: Discovery and molecular basis of subtype-selective cyclophilin inhibitors.
Article Snippet: Preparative high-performance liquid chromatography (HPLC) reverse phase purification was conducted with an Agilent 6100 Quadrupole liquid chromatography–mass spectrometry (LC–MS) system using a Kinetex 5 μm C18 100 Å, AXIA Packed LC Column 150 ×30.0 mm (Phenomenex). .. Silica gel column chromatography was conducted with a Biotage SP1 Flash Chromatography system. ..

Purification:

Article Title: Dopamine D
Article Snippet: Purification may also be performed using Biotage® Isolera or Biotage® SP1 flash chromatography systems, these instruments work with Biotage® KP-SIL cartridges, Biotage® KP-NH cartridges or Biotage® KP-C18 cartridges. .. Purification may also be performed using Biotage® Isolera or Biotage® SP1 flash chromatography systems, these instruments work with Biotage® KP-SIL cartridges, Biotage® KP-NH cartridges or Biotage® KP-C18 cartridges. ..

Chromatography:

Article Title: Dopamine D
Article Snippet: Purification may also be performed using Biotage® Isolera or Biotage® SP1 flash chromatography systems, these instruments work with Biotage® KP-SIL cartridges, Biotage® KP-NH cartridges or Biotage® KP-C18 cartridges. .. Purification may also be performed using Biotage® Isolera or Biotage® SP1 flash chromatography systems, these instruments work with Biotage® KP-SIL cartridges, Biotage® KP-NH cartridges or Biotage® KP-C18 cartridges. ..



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